Mathematical modelling of OAS2 activation by dsRNA and effects of dsRNA lengths
نویسندگان
چکیده
The activation of 2'-5'-oligoadenylate synthetase (OAS) enzymes by direct interaction with viral double-stranded RNA (dsRNA) is a key part the innate immune response to infection. A downstream effect OAS-dsRNA degrade single-stranded prevent spread virus. OAS2, one members OAS family, depends on dsRNA length. Combining in vitro experiments and mathematical modelling, we test different hypotheses for OAS2 mechanisms its cofactor dsRNA. After model calibration selection, cooperative binding multiple single shown best represent length enzyme activity.
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ژورنال
عنوان ژورنال: AIMS mathematics
سال: 2021
ISSN: ['2473-6988']
DOI: https://doi.org/10.3934/math.2021351